
Experimental toxicology
Laboratory teams develop and validate new in vitro methods that capture how chemicals affect human cells and tissues.
Meet the researchers, toxicologists and coordinators behind a joint European effort to make chemical risk assessment animal-free, sustainable and reliable.
ASPIS cluster is a joint collaboration of the H2020 funded projects ONTOX, PrecisionTOX and RISKHunt3R. Each project brings its own scientific focus, while shared coordination keeps the work aligned across partners and countries.
Partners work towards a common goal: replacing animal-based testing with modern, human-relevant approaches to chemical safety.
Toxicologists, computational scientists, data specialists and regulatory experts collaborate in joint working groups.
Clear reporting lines and joint meetings ensure that results from each project feed into the wider cluster outcomes.

The cluster combines laboratory science with computational modelling. Teams share data, methods and protocols so that findings from one project can be tested and reused by the others.
Each project has its own team structure, yet all of them contribute to the same overarching objective of reliable, animal-free risk assessment.

Laboratory teams develop and validate new in vitro methods that capture how chemicals affect human cells and tissues.

Modelling specialists build tools that integrate existing knowledge, predict hazards and support decisions without new animal studies.
A short overview of how partners collaborate day to day.
Each project appoints its own scientific lead and work package leaders. Cross-project tasks are coordinated through a joint steering group that meets regularly.
Partners publish harmonised protocols, open data resources and joint reports, so that methods developed in one project can be adopted across the cluster.
Regulators, industry safety assessors and the public all benefit from faster, more reliable chemical safety evaluations that respect animal welfare.

Beyond individual results, the cluster is building a network of people who will continue to shape chemical risk assessment long after the projects close. Training, exchange visits and joint meetings help early-career researchers gain experience across disciplines.
Reach out to the ASPIS cluster to learn about our partners, our projects and opportunities for collaboration.
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